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This 41-year-old college-educated former professional football player retired before the age of 30 due to multiple knee injuries. His wife requested evaluation of her husband 15 years later because of her concerns that he might have chronic traumatic encephalopathy (CTE) related to innumerable concussions sustained during his football career. Chronic multi-focal pain, anxiety and sleep disturbance, as well as alcohol and marijuana dependence, were noted at the time of his assessment.